Modelling Kallmann syndrome in the zebrafish
نویسندگان
چکیده
........................................................................................ 3 Acknowledgements ....................................................................... 4 Table of
منابع مشابه
Characterization of the two zebrafish orthologues of the KAL-1 gene underlying X chromosome-linked Kallmann syndrome
The gene underlying X chromosome-linked Kallmann syndrome, KAL-1, has been identified for several years, yet its role in development is still poorly understood. In order to take advantage of the zebrafish as a model in developmental genetics, we isolated the two KAL-1 orthologues, kal1.1 and kal1.2, in this species. Comparison of deduced protein sequences with the human one shows 75.5 and 66.5%...
متن کاملAnosmin - 1 a is required for fasciculation and
The KAL-1 gene underlies the X-linked form of Kallmann syndrome (KS), a neurological disorder that impairs the development of the olfactory and GnRH systems. KAL-1 encodes anosmin-1, a cell matrix protein that shows cell adhesion, neurite outgrowth, and axon-guidance and -branching activities. We used zebrafish embryos as model to better understand the role of this protein during olfactory syst...
متن کامل22-P006 The zebrafish as an in vivo model of drug-induced hearing and vestibular impairment
Gonadotropin releasing hormone (GnRH) is a multifunctional decapeptide that possess endocrine as well as neuromodulatory roles and is present in all vertebrates. Endocrine GnRH cells play a crucial role in the establishment of the hypothalamic–pituitary– gonadal axis in many species. Recent studies have found that the prokineticin2 (pk2) and prokineticin receptor2 (pkr2) genes are involved in t...
متن کامل22-P004 Effect of the disruption of prokineticin2 system in the development of zebrafish hypothalamic GnRH cells
Gonadotropin releasing hormone (GnRH) is a multifunctional decapeptide that possess endocrine as well as neuromodulatory roles and is present in all vertebrates. Endocrine GnRH cells play a crucial role in the establishment of the hypothalamic–pituitary– gonadal axis in many species. Recent studies have found that the prokineticin2 (pk2) and prokineticin receptor2 (pkr2) genes are involved in t...
متن کاملWDR11‐mediated Hedgehog signalling defects underlie a new ciliopathy related to Kallmann syndrome
WDR11 has been implicated in congenital hypogonadotropic hypogonadism (CHH) and Kallmann syndrome (KS), human developmental genetic disorders defined by delayed puberty and infertility. However, WDR11's role in development is poorly understood. Here, we report that WDR11 modulates the Hedgehog (Hh) signalling pathway and is essential for ciliogenesis. Disruption of WDR11 expression in mouse and...
متن کاملذخیره در منابع من
با ذخیره ی این منبع در منابع من، دسترسی به آن را برای استفاده های بعدی آسان تر کنید
عنوان ژورنال:
دوره شماره
صفحات -
تاریخ انتشار 2011